Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress
نویسندگان
چکیده
منابع مشابه
Mary Reversible , Specific , Active Aggregates of Endogenous Proteins Assemble upon Heat Stress Edward
| Full Text HTML | Full Text PDF (945 KB) | Full Text PDF with Links (603
متن کاملReversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress
Heat causes protein misfolding and aggregation and, in eukaryotic cells, triggers aggregation of proteins and RNA into stress granules. We have carried out extensive proteomic studies to quantify heat-triggered aggregation and subsequent disaggregation in budding yeast, identifying >170 endogenous proteins aggregating within minutes of heat shock in multiple subcellular compartments. We demonst...
متن کاملDeubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress
Elimination of misfolded proteins is crucial for proteostasis and to prevent proteinopathies. Nedd4/Rsp5 emerged as a major E3-ligase involved in multiple quality control pathways that target misfolded plasma membrane proteins, aggregated polypeptides and cytosolic heat-induced misfolded proteins for degradation. It remained unclear how in one case cytosolic heat-induced Rsp5 substrates are des...
متن کاملProteome profiling of Populus euphratica Oliv. upon heat stress.
BACKGROUND AND AIMS Populus euphratica is a light-demanding species ecologically characterized as a pioneer. It grows in shelter belts along riversides, being part of the natural desert forest ecosystems in China and Middle Eastern countries. It is able to survive extreme temperatures, drought and salt stress, marking itself out as an important plant species to study the mechanisms responsible ...
متن کاملTranscriptome Profiles of Populus euphratica upon Heat Shock stress
Heat stress, which strongly affects plant performance and often results in reduced vegetative growth and yields depression, has become an increasingly serious global problem. Populus euphratica Oliv. which has been considered as a tree model for the study of plant response to abiotic stresses, could be resistant to an extremely wide environmental temperature range (-40 °C to 45 °C). Previous st...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2015
ISSN: 0092-8674
DOI: 10.1016/j.cell.2015.08.041